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Combipro

cGMP 3-in-1 Combination Sterilizers

Pharmaceutical production facilities and CDMOs with diverse product lines require sterilization equipment that adapts to varying load types without compromise. The Combipro is a fully custom, cGMP sterilizer engineered to perform vacuum-steam, steam-air mixture, and hot water cascade sterilization cycles in a single chamber, eliminating the need for multiple sterilizers across your operation. Built with non-proprietary components and backed by a comprehensive documentation package, the Combipro delivers the process flexibility, compliance and long-term serviceability that contract manufacturing facilities demand.
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Purpose-Built

The Combipro is designed and built around your exact facility, workflow, and load requirements, ensuring seamless integration rather than forcing your operation to adapt to a fixed sterilizer design.

Reliable

High-grade, non-proprietary components and sanitary, 316L stainless steel construction ensures lasting durability and keeps your production moving. Backed by a 15-year chamber warranty and U.S.-based field service.

Versatile

Combipro sterilizers handle dry goods, liquid pharmaceuticals, and large-volume liquids without requiring separate units for each process. For heat-sensitive containers, the sterilizer can also be equipped with ports and controls for gas sterilization like H2O2.

Validated

Proven compliance backed by a comprehensive factory documentation package, GAMP 5-compliant PLC controls, and full 21 CFR Part 11 support. Available IQ/OQ protocols and validation support helps your team move from installation to qualified operation with confidence.

110°C — 135°C

Sterilization Temperature

±0.5°C

Temperature Uniformity

3-in-1

Pre-Vacuum - Steam, Steam-Air Mixture Hot Water Cascade Sterilization Process

15 Years

Chamber Warranty

Engineered around your process. Not a catalog spec.

Purpose-built to your exact requirements and assembled with non-proprietary components for a process-perfect fit with zero vendor lock-in.

We do not adhere to a one-size-fits-all philosophy when designing sterilizers for cGMP production. Instead, we map out your process, facility constraints, and available utilities to configure a solution that perfectly aligns with your operations. Assembled with all non-proprietary components, the Combipro gives you the freedom to source parts openly, eliminating exclusive service agreements, inflated OEM parts pricing, and single-supplier lock-in. Standard parts are readily available, and your service relationship is built on value, not obligation.

Custom Chamber Dimensions

Pass-Through

Single Door

Floor Mounted

Pit Mounted

Right Service Access

Left Service Access

Integrated Steam Generator

Standalone Steam Generator

Electric Steam Generator

Steam-to-Steam Generator

Custom Cycle Recipes

Custom Loading Equipment

Built for cGMP Production

Durable chamber construction to support consistent sterilization performance and long-term reliability.

The Combipro is built for durability and compliance in demanding pharmaceutical environments. A fully 316L stainless steel construction and precision-finished chamber surfaces simplify cleaning and resist corrosion under repeated sterilization cycles. Seamless chamber design, sanitary welded joints, and fully drainable chamber and piping eliminate standing water and minimize contamination risk, reducing maintenance requirements and unplanned downtime.

The chamber vessel and door are constructed entirely from 316L stainless steel with no dissimilar metals, eliminating corrosion risk and ensuring long-term durability and cleanability in regulated production environments. Precision machined brackets retain the door on all four sides for smooth, consistent travel and a secure seal every cycle.

All process piping and fittings are constructed from 316L stainless steel with sanitary clamp connections sloped to drain with no dead legs, eliminating moisture traps, reducing contamination risk, and simplifying cleaning validation throughout the system.

Fully insulated chamber and piping systems maintain temperature setpoints throughout the cycle, minimize heat loss, and reduce energy and utility consumption without any impact on cycle performance.

Lubricant-free gaskets eliminate particle shedding into cleanrooms while extending service life. No lubricant means no contamination risk and less maintenance variables to manage in a regulated production environment.

Standard equipped on every Combipro, non-contact photoelectric sensors provide instant obstruction detection and trigger immediate door reversal through the PLC, eliminating the mechanical contact points and wear components of traditional spring-loaded systems.

Precision Control. Validated Performance.

GAMP 5-compliant PLC controls for repeatable performance, cycle after cycle.

Built on industrial-grade Allen-Bradley or Siemens PLC platforms and developed in accordance with GAMP 5 guidelines, the Combipro control system delivers the process repeatability, system reliability, and validation support that regulated production environments require.
  • Programmable with any combination of pre-vacuum and gravity cycles with configurable parameters for each cycle phase.
  • Up to 50 cycle recipes securely stored in the control system memory.
  • Multi-level authentication prevents unauthorized recipe modifications.
  • Instant recipe retrieval via large touchscreen operator interface.
  • 21 CFR Part 11 compliant electronic records and signatures.
  • Available Ethernet/IP and OPC UA for integration with plant SCADA, building automation, and MES systems.

Combipro Sterilization Cycles

Matched to your load type and sterilization requirements to ensure effective steam penetration while protecting product integrity.

Pre-Vacuum with Drying

Sterilization of porous and dry goods, including wrapped materials, filters, linens, rubber stoppers, and filling line components. Alternating vacuum and steam pulses ensure thorough steam penetration throughout the load, followed by a rapid drying phase that leaves goods dry and ready for immediate use.

Gravity Air Removal

Sterilization of glassware, instruments, waste, and liquids in open or vented containers. Steam displaces air from the chamber by gravity, providing effective sterilization without the mechanical stress of vacuum cycling and protecting container integrity throughout the process.

Gravity Air Removal with Active Cooling

Sterilization of liquids in loose or tightly sealed containers that are heat or pressure sensitive. Following the sterilization exposure phase, cooling water is introduced to the chamber jacket to accelerate cooling while maintaining pressure support, protecting sensitive containers from damage or deformation.

Steam-Air Mixture

Terminal sterilization of vials, ampoules, and syringes in sealed containers that are heat or pressure sensitive. Internal fans circulate the steam-air mixture for uniform temperature distribution throughout the chamber while overpressure control protects sensitive containers from deformation or rupture during the cycle.

Hot Water Cascade

Terminal sterilization of large volume parenterals, IV bags, and liquid-filled containers. Superheated purified water is cascaded over the load while compressed air is simultaneously injected to maintain an overpressure, preventing container damage or deformation while achieving rapid, uniform heat penetration throughout the load.

*Custom cycle parameters and recipes are available for specialized load types and process requirements. Contact a BMT USA engineer to discuss your specific sterilization application.

Pure Steam. Fully Integrated.

cGMP-compliant pure and clean steam generation available as an integrated or standalone solution for every production environment.

BMT USA steam generators are available in clean steam and pure steam configurations and can be integrated directly into the Combipro or configured as a standalone centralized steam source. In addition to standard horizontal configurations, BMT USA is one of the only manufacturers also offering integrated electric pure or clean steam generators with a vertical vessel design, delivering 400 lbs/hr output capacity with a significantly reduced facility footprint.

BMT USA steam generators are available in clean steam configurations for general cGMP sterilization use or can be fitted with a pure steam separator to produce WFI-quality pure steam meeting the strictest pharmacopeial standards.

BMT USA pure and clean steam generators can be integrated directly into the Combipro for an all-in-one solution that simplifies installation, reduces utility connections, and minimizes facility footprint. Alternatively, the generator can be configured as a standalone centralized steam source serving multiple sterilizers across your facility.

BMT USA is one of the only manufacturers offering integrated electric pure steam generators with a vertical vessel design. Where most electric generators require a horizontal footprint, the vertical vessel can produce up to 400 lbs/hr of pure or clean steam @ 80 PSIG while using significantly less floor space, providing a meaningful advantage in space-constrained pharmaceutical production environments.

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Combipro Chamber Sizes

Combipro sterilizers are offered in a range of chamber sizes and volumes. The table below contains some of our standard models; however, we can design and build a customized solution to match your exact requirements.

Model

Chamber Volume
cu. ft. (liters)

Internal
Dimensions
w x h x d (mm)

Estimated Overall Dimensions
w x h x d (mm)

Mounting

Door Slide Direction

CPP 202038

8.8 (227)

20″ x 20″ x 38″
508 x 508 x 965 mm

60” x 74” x 50”
1524 x 1880 x 1270 mm

Floor

Vertical

CPP 262639

15.8 (447)

26″ x 26″ x 39″
660 x 660 x 990 mm

66” X 80” X 51”
1676 x 2032 x 1296 mm

Floor

Vertical

CPP 262649

19 (538)

26″ x 26″ x 49″
660 x 660 x 1245 mm

66” x 80” x 61”
1676 x 2032 x 1541 mm

Floor

Vertical

CPP 263639

21 (595)

26″ x 36″ x 39″
660 x 914 x 990 mm

66” x 96” x 51”
1676 x 2438 x 1296 mm

Floor

Horizontal

CPP 263648

25.9 (733)

26″ x 36″ x 48″
660 x 914 x 1220 mm

66” x 96” x 60”
1676 x 2438 x 1524 mm

Floor

Horizontal

CPP 263660

32.5 (920)

26″ x 36″ x 60″
660 x 914 x 1524 mm

66” x 96” x 72”
1676 x 2438 x 1829 mm

Floor

Horizontal

CPP 363648

36 (1019)

36″ x 36″ x 48″
914 x 914 x 1220 mm

128” x 96” x 60”
3251 x 2438 x 1524 mm

Floor

Horizontal

CPP 363660

45 (1274)

36″ x 36″ x 60″
914 x 914 x 1524 mm

128″ x 96″ x 72″
3251 x 2438 x 1828 mm

Floor

Horizontal

CPP 375760

73.2 (2073)

37″ x 57″ x 60″
940 x 1448 x 1524 mm

129″ x 114″ x 72″
3277 x 2896 x 1828 mm

Floor

Horizontal

CPP 375786

102.4 (2899)

37″ x 57″ x 86″
940 x 1448 x 2184 mm

129″ x 114″ x 98″
3277 x 2896 x 2489 mm

Floor or Pit

Horizontal

CPP 484860

80 (2265)

48″ x 48″ x 60″
1219 x 1219 x 1524 mm

148″ x 108″ x 72″
3759 x 2743 x 1829 mm

Floor or Pit

Horizontal

CPP 484872

96 (2718)

48″ x 48″ x 72″
1219 x 1219 x 1829 mm

148″ x 108″ x 84″
3759 x 2743 x 2133 mm

Floor or Pit

Horizontal

CPP 484886

114.5 (3242)

48″ x 48″ x 86″
1219 x 1219 x 2184 mm

148″ x 108″ x 98″
3759 x 2743 x 2489 mm

Floor or Pit

Horizontal

CPP 495748

77.5 (2195)

49″ x 57″ x 48″
1244 x 1448 x 1219 mm

149″ x 114″ x 60″
3784 x 2896 x 1524 mm

Floor or Pit

Horizontal

CPP 495760

96.9 (2743)

49″ x 57″ x 60″
1244x 1448 x 1524 mm

149″ x 114″ x 72″
3784 x 2896 x 1829 mm

Floor or Pit

Horizontal

CPP 495772

116.3 (3293)

49″ x 57″ x 72″
1244 x 1448 x 1829 mm

149″ x 114″ x 84″
3784 x 2896 x 2133 mm

Floor or Pit

Horizontal

CPP 495786

138.8 (3930)

49″ x 57″ x 86″
1244 x 1448 x 2184 mm

149″ x 114″ x 98″
3784 x 2896 x 2489 mm

Floor or Pit

Horizontal

CPP 495796

155 (4389)

49″ x 57″ x 96″
1244 x 1448 x 2438 mm

149″ x 114″ x 110″
3784 x 2896 x 2794 mm

Floor or Pit

Horizontal

CPP 488660

143 (4049)

48″ x 86″ x 60″
1219 x 2184 x 1524 mm

148″ x 133″ x 72″
3759 x 3378 x 1829 mm

Floor or Pit

Horizontal

CPP 488686

205 (5805)

48″ x 86″ x 86″
1219 x 2184 x 2184 mm

148″ x 133″ x 98″
3759 x 3378 x 2489 mm

Floor or Pit

Horizontal

CPP 548686

230.7 (6531)

54″ x 86″ x 86″
1371 x 2184 x 2184 mm

166″ x 133″ x 98″
4216 x 3378 x 2489 mm

Floor or Pit

Horizontal

Validation Flange

Individually seals each thermocouple lead wire, allowing a single failed wire to be replaced without disturbing surrounding thermocouple seals, significantly reducing downtime during validation and maintenance. Available for 16 or 24 load probes with 1½” or 2″ tri-clamp validation port compatibility. Custom sizes available upon request.

Sterilizer Trays

Custom-designed and manufactured in 316L stainless steel to maximize chamber capacity and accommodate vials, ampoules, and other materials requiring specialized handling. Configured to your exact load and finished to your specifications.

Sterilizer Carts

316L stainless steel carts designed for loading materials, containers, and equipment into the sterilizer chamber. Compatible with transfer trolleys for floor-mounted units and pit-mounted configurations. Carts can be custom designed to match your load and workflow.

Transfer Trolleys

Provides a stable, level platform for moving loaded carts to and from the sterilizer. The cart locks securely to the trolley when away from the sterilizer and releases only when the trolley is docked flush with the chamber rails, ensuring smooth, safe transfer every cycle.

Heated Air Option

Assists in drying hard-to-dry loads such as rubber stoppers and double-wrapped bags. Chamber air passes through an electrically heated heat exchanger and a 0.2-micron filter before entering the chamber, improving drying performance without compromising sterility.
Steam Sample Port installed on a BMT USA pure steam generator

Clean Steam Sample Port

Integrated into the sterilizer or standalone steam generator, this system includes a condenser, conductivity meter, and probe installed on the pure steam outlet. A sample port allows condensed steam samples to be collected for quality testing and compliance documentation.

Steam Separator

Removes residual moisture and liquid droplets from clean steam to improve steam quality and dryness before it enters the sterilization chamber. Ensures consistent, dry saturated steam for reliable cycle performance and load protection.
Steam Sterilizer Seismic Leveling Feet

Seismic Leveling Feet

Adjustable leveling feet with a 360° pivoting ball joint for positioning on uneven surfaces without lifting the unit. Includes floor-bolt holes for securing the sterilizer in seismic zones.

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